Immune Inflammatory Response

To the tune of "Drivers License" by Olivia Rodrigo
Macrophages produce cytokines
Which act on various effectors
Such as the hypothalamus
Increasing body temperature
This increases the efficiency of macrophage phagocytosis
Cytokines act on blood vessels
Causing vasodilation
They allow for adhesion
Of cells to the endothelium
Through the increased expression of receptors on the endothelium
An effective immune response requires cells to migrate
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation
Once cells leave the blood vessels
They travel to the infection
Using chemokine receptors
To move down chemotactic gradients
Cytokines travel through the body and interact with tissues and organs
An effective immune response requires cells to migrate
Oh-oh-oh
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation
Selectins, integrins, allow for leukocytes
To adhere, right near the infection site
Immunoglobulins are ligands for the integrin family
Ooh, ooh, ooh, ooh
Integrins and ICAM, bind tightly sending
A signal to the endothelial coating
So that the leukocytes can exit the blood vessels
Ooh, ooh, ooh, ooh
An effective immune response requires cells to migrate
Use of addressins and a chemotactic gradient to locate
This brings leukocytes to the site of the infection
Where cytokines can induce local inflammation
Cytokines can induce local inflammation