Calcium Homeostasis
To the tune of "Happy Xmas" by John Lennon
The PMCA
ATP driven pump
It helps to maintain
Levels of calcium
Regulatory domain
Autoinhibits the pump
The pump is stimulated
By calmodulin
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
The NCX
Swaps three sodium
Across the membrane
For one calcium
This action depends
On a gradient
For sodium ions
That is pre-established
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
Calcium enters
Intermembrane space
Of mitochondria
Through voltage-gating
It enters the matrix
Through uniporters
Very negative potentials
Are the main driving force
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
Intracellular
Calcium levels
Are in kept in
Homeostasis
The PMCA
ATP driven pump
It helps to maintain
Levels of calcium
Regulatory domain
Autoinhibits the pump
The pump is stimulated
By calmodulin
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
The NCX
Swaps three sodium
Across the membrane
For one calcium
This action depends
On a gradient
For sodium ions
That is pre-established
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
Calcium enters
Intermembrane space
Of mitochondria
Through voltage-gating
It enters the matrix
Through uniporters
Very negative potentials
Are the main driving force
Calcium fluxes
During "on" reactions
They match exactly
With "off" reactions
Intracellular
Calcium levels
Are in kept in
Homeostasis
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